Research focuses on the long-term cognitive development of children, including healthy infants and those afflicted by a newborn brain injury. The research lab aims to identify imaging, neurophysiological, and behavioral biomarkers that will help predict executive dysfunction and cognitive disability in populations at risk.
My research focuses on speech motor control: how the brain coordinates sensory and motor signals to achieve communicative goals. Our lab combines brain imaging during spoken language with the acoustic analysis of speech behavior.
Our lab uses zebrafish to study neuronal cell biology. We are interested in mitochondrial homeostasis, autophagy, and microtubule regulation, which are all essential for the formation and maintenance of neural circuits.
In the Gomez lab we seek to improve our understanding of the molecular basis of normal neural network formation during development and how defects in connectivity occur in ASDs, such as Tuberous Sclerosis Complex (TSC).
Our lab uses neuroimaging and fluid biomarkers to investigate the sequence and timing of Alzheimer’s disease pathologic and clinical events. We also perform antemortem-postmortem studies comparing imaging and fluid biomarkers acquired during life to pathological characterization of tissue after death.
The main projects center on noradrenergic mechanisms of vocalization/swallow/GI deficits in Parkinson disease using a translational approach (Pink1-/- rat model). We use behavior, histology, PCR, and microPET imaging to study how exercise and drugs might rescue these deficits. We are also interested in how pathology might spread from gut to central nervous system.
Using neuroscience, psychology, and psychiatry, we are exploring brain-body mechanisms of vulnerability and resilience to childhood trauma. Modalities include behavioral assessment, neuroimaging, psychophysiology, machine learning, and others.
Understanding the mechanisms linking aging to neurodegeneration. Role of glial cells in the progression of neurodegenerative diseases, including Amyotrophic Lateral Sclerosis (ALS) and Alzheimer’s disease.
The research in my laboratory investigates the principles and neural mechanisms of visual processing, perceptual organization, attention, conscious perception, decision-making, visually guided eye movement control, and neural coding.
Cellular, synaptic and circuit function in the retina. Functional maturation of neurons and circuits during early stages of retina development in primates and human stem cell derived retinal organoids.