Justin Wolter

Position title: Assistant Professor, Department of Genetics

Email: wolter4@wisc.edu




Ph.D. in Molecular and Cellular Biology, Arizona State University, Tempe, AZ, USA
Postdoctoral in Molecular Genetics of Neurodevelopmental Disorders, University of North Carolina, Chapel Hill, NC, USA

Research Description:

My primary scientific interest is how genetic variation shapes brain development. By leveraging my training in genetics, molecular biology, cell biology, and neurodevelopment, my lab is studying how genetic variation both common and rare alters neurodevelopment, and in turn influences risk and resilience to neurological disorders. This broad interest has led me to study several neurological disorders, including autism spectrum disorder, bipolar disorder, and ataxia. There are many common features across these disorders, allowing us to develop tools and resources that can be applied broadly to understanding underlying molecular deficiencies. In the past several years my work has focused on two questions: 1. How does common genetic variation affect molecular and cellular phenotypes in autism spectrum disorder, and 2. What neurodevelopmental processes predispose a neuron to neurodegenerative insult, and what pathways do cells employ to survive? To answer these questions we use both human induced pluripotent stem cells (iPSCs) and classic genetic mouse models, and technologies such as massively parallel cell culture, single cell RNAsequencing, and proteomics.

Link to Lab Website

Link to Publications