Mathew V. Jones
Position title: Associate Professor
Phone: (608) 263-4394
Ph.D. in Pharmacological and Physiological Sciences, University of Chicago
My research has consistently addressed the basic mechanisms of GABAA receptor function and pharmacology relevant to understanding and treating human health problems. I hold a B.A. in Biological Sciences and a Ph.D. in Physiological and Pharmacological Sciences from the University of Chicago. My Ph.D. thesis research in the lab of Neil Harrison focused on understanding the mechanisms of general anesthetic action, and included one of the first demonstrations that volatile anesthetics enhance inhibitory synaptic transmission and GABAA receptor single channel activity at concentrations that correlate with their clinical potency for producing anesthesia. I extended this work as a postdoctoral fellow in the lab of Gary Westbrook at The Vollum Institute, where I used submillisecond solution exchange techniques to dissect GABAA receptor kinetics, and to develop a mathematical model of receptor function that has become a standard tool used by many other researchers in the field. More recent projects include analysis of dentate gyrus circuit function relevant to memory deficits in epilepsy and machine-learning analysis of EEG signals in epilepsy. I am also quite interested in understanding the bidirectional interactions between epilepsy and sleep disruptions.
Patch-clamp, EEG, epilepsy, sleep, computational