Katie Drerup

Department:

Integrative Biology

Education:

M.S. in Neuroscience, Bowling Green State University, Bowling Green, OH, USA
Ph.D. in Neuroscience, Northwestern University, Evanston, IL, USA
Postdoctoral, Oregon Health & Science University, Portland, OR, USA

Research Description:

While we know that mitochondrial transport is critical for the maintenance of the nervous system exactly how they are maintained as a population is not entirely clear. A primary goal of my lab is to address this overarching question critical for both basic and clinical neuroscience. To date, we have taken a three–pronged approach towards addressing this question. First, we implemented a forward genetic screen to dissect the molecular regulation of mitochondrial transport in axons, focusing on retrograde transport by the Cytoplasmic dynein motor. Second, we developed novel imaging techniques to image axonal transport, mitochondrial health, and mitochondrial function in vivo in zebrafish. This vertebrate allows us to analyze intracellular processes in a complete intact animal without disrupting the neural circuit niche. Third, we have sought out specialized collaborators to facilitate our work including those focused on lipidomics and protein lipid interactions.

Key Words:

Neuronal Cell Biology, Axonal Transport, Retrograde Transport, Zebrafish

Diversity Statement:

As a mentor, I aim to promote inclusivity in my lab while instilling rigorous and unbiased experimental design, methodology, analysis, interpretation, and reporting of results. Our lab values diversity and the positive impact it makes on our lab, our work, and the NTP program. We work to encourage open dialogue and also the representation of underrepresented groups in our lab and department. In summary, though a junior investigator, I have substantial experience mentoring young scientists and am enthusiastic about promoting the next generation to continue our work on mitochondrial maintenance in neurons.

Link to Lab Website

Link to Publications