Position title: Professor
Phone: (608) 262-5014
Ph.D. in Molecular Biology, University of Wisconsin-Madison
We are interested in the cellular/molecular bases of memory consolidation in Drosophila. Work in all organisms is consistent with a requirement for de novo protein synthesis around the time of training, and during later “windows”, although there are periodic claims to the contrary. Recent work shows that mechanisms associated with both synaptic and systems consolidation are used over a 3+ day post-training period. The transition to the long-lasting phase of memory is particularly interesting, since it involves mechanisms associated with sleep and circadian processes, but not others that are needed earlier. The ultimate goal is to understand when, where and why protein synthesis is needed, and how these requirements can help explain discrepant data suggesting a non-requirement for gene expression during consolidation.
Memory consolidation, gene expression