Department:
Pathology and Laboratory Medicine
Education:
Ph.D. in Molecular and Cellular Biology, University of Iowa
Research Description:
Research in the Ulland lab utilizes cellular, biochemical, molecular, and in vivo models to explore the role of metabolism and metabolites in modifying the microglial response in AD pathology. The Ulland lab is a strong interdisciplinary environment that integrates both immunopathological and neuropathological research to interrogate questions regarding the innate immune response in neurodegeneration. Our team of trainees and professional specialists are working to further understand how metabolic and transcriptional changes in microglia induced by systemic inflammation influence the microglial response during AD pathogenesis, exploring how metabolic changes brought about by AD pathology can shape the innate immune response to AD, examining the impact of host microbiota and microbiota-derived metabolites on microglial function in AD, and working towards the development of novel therapeutic strategies aimed at modulating microglial responses in AD.
Key Words:
Neuroimmunology, neuroinflammation, Alzheimer’s disease, microglia