Tyler Ulland

Assistant Professor, Department of Pathology and Laboratory Medicine




Ph.D.  University of Iowa

Lab Website:


Research Focus:

My lab focuses on the innate immune response during neurodegeneration with a special emphasis on Alzheimer’s disease.  We utilize a combination of animal models, clinical samples, and publicly available data to guide our work.  We currently have projects focused on how inflammation influences microglia responses in AD, how metabolites can control microglial function, and more generally the function of microglia in AD.

NTP Research Strengths:

Neurobiology of Disease, Molecular Neuroscience


Ulland, T.K. and Colonna, M. TREM2, a Key Player in Microglia Biology and Alzheimer’s Disease. Nat. Rev. Neurol. 14, 667-675, 2018.

Zhou, Y., Ulland, T.K., and Colonna, M. Trem2-dependent effects on microglia in Alzheimer’s Disease. Front. Aging Neurosci. 10, 202 eCollection, 2018.

Ulrich J.D.*, Ulland, T.K.*, Mahan, T.E.*, Nilsson, P., Song, W., Jiang, H., Stewart, F., Anderson, E., Wang, Y., Colonna, M., and Holtzman, D.M. ApoE Facilitates the Microglial Response to Amyloid Pathology. J. Exp. Med. 215, 1047-1058, 2018. * indicates equal contribution.

Song, W.*, Joshita, S.*, Zhou, Y., Ulland, T.K., Gilfillan, S., and Colonna, M. Humanized TREM2 mice reveal microglia-intrinsic and –extrinsic loss of function effects of R47H polymorphism. J. Exp. Med. 215, 745-760, 2018. * indicates equal contribution.

Robinette, M.L. Cella, M., Telliez, J.B., Ulland, T.K., Barrow, A.D., Capuder, A., Gilfillan, S., Lin, L- L., Notarangelo, L.D., and Colonna, M. Jak3 deficiency blocks innate lymphoid cell development. Mucosal Immunol. 11, 50-60, 2018.

Clay, G.C., Graff, J.W., Ulland, T.K., Valadares, D., Davis, R.E., Scorza, B.M., Sudan, B., Sutterwala, F.S., and Wilson, M.E. Anti-inflammatory Role for NLRP10 in Murine Cutaneous Leishmaniasis. J. Immunol. 199, 2823-2833, 2017.

Ulland, T.K.*, Song, W.*, Huang, S.C., Ulrich, J.D., Sergushichev, A., Beatty, W.L., Cairns, N.J., Kambal, A., Loginicheva, E., Gilfillan, S., Cella, M., Virgin, H.W., Unanue, E.R., Holtzman, D.M., Artyomov, M.N., and Colonna, M. TREM2 is Required to Meet the Metabolic Demands of Microglia in Alzheimer’s Disease. Cell 170, 649-663, 2017. * indicates equal contribution. Previewed in Hong, S. and Stevens, B. Cell Metab. 26 (4), 590-591, 2017.

Cortez, V., Ulland, T.K., Bando, J., Robinette, M., Wang, Q., White, A.J., Gilfillan, S., Cella, M., and Colonna, M. SMAD4 Impedes Conversion of NK Cells into ILC1-like Cells by Curtailing Non-canonical TGFβ Signaling. Nat. Immunol. Published online ahead of print July 31, 2017.

Keren-Shaul, H., Spinrad, A., Weiner, A., Matcovitch-Natan, O., Dvir, R., Ulland, T.K., David, E., Baruch, K., Lara-Astaiso, D., Toth, B., Itzkovitz, S., Colonna, M., Schwartz, M., Amit, I. Single Cell RNA- seq Identifies a Unique Microglia Type Associated with Alzheimer’s Disease. Cell Jun 15; 169(7): 1276-1290, 2017. Featured in a Perspective in Science (356, 1123-1124, 2017) and a Preview in Cell (Jun 15 169(7): 1172-1174, 2017).

Ulrich, J.D., Ulland, T.K., Colonna, M., and Holtzman, D.M. Elucidating the role of TREM2 in Alzheimer’s disease. Neuron. Apr 19; 94(2): 237-248, 2017.

Song, W., Hooli, B., Mullin K., Jin S.C., Cella M., Ulland T.K., Wang Y., Tanzi R., Colonna M. Alzheimer’s Disease-associated TREM2 Variants Exhibit Either Decreased or Increased Ligand-dependent Activation. Alzheimer’s Dement. Apr; 13(4): 381-387, 2017. Will be featured in News and Views of Nat. Rev. Neurol.

Robinette, M.L., Bando, J.K., Song, W., Ulland, T.K., Gilfillan, S., and Colonna, M. IL-15 Sustains IL-7R- Independent ILC2 and ILC3 Development. Nat. Commun. Mar 31;8:14601, 2017.

Ulland, T.K.*, Jain, N.*, Hornick, E.E., Elliott, E.I., Clay, G.C., Sadler, J., Mills, K.A.M., Janowski, A.M., Volk, A.P.D., Wang, K., Legge, K.L., Lokesh, G., Bourdi, M., Ferguson, P.J., Wilson, M.E., Cassel, S.L., Sutterwala,

F.S. Nlrp12 Mutation in C57BL/6J Mice Results in a Substrain-specific Defect in Neutrophil Recruitment. * indicates equal contribution. Nat. Commun. Oct; 7: 13180, 2016.

Wang, Y.*, Ulland, T.K.*, Ulrich, J.D.*, Song, W., Yuan, P., Mahan, T.E., Shi, Y., Gilfillan, S., Cella, M., DeMattos, R.B., Grutzendler, J., Cirrito, J.R., Holtzman, D.M.#, and Colonna, M.# TREM2- mediated Early Microglial Response Limits Diffusion and Toxicity of Amyloid Plaques. * indicates equal contribution. # indicates co-corresponding authors. J. Exp. Med. Apr; 213(5): 667-675, 2016. Featured on the cover.

Ulland, T.K., Wang, Y., and Colonna, M. Regulation of Microglial Survival and Proliferation in Health and Diseases. Semin. Immunol. Dec; 27(6): 410-415, 2015.

Wang, Y., Bugatti, M., Ulland, T.K., Vermi, W., Gilfillan, S., and Colonna, M. Non-redundant Roles of Keratinocyte-derived IL-34 and Neutrophil-derived CSF1 in Langerhans Cells Renewal in the Steady-state and Skin Inflammation. Eur. J. Immunol. Mar; 46(3): 552-559, 2016.

Ulland, T.K., Ferguson, P.J., and Sutterwala, F.S. Modulation of Inflammasome Activation by Microbial Pathogens as a Survival Strategy: the Consequences of Evasion. J. Clin. Invest. Feb; 125(2): 469- 477, 2015.

Chen, G., Wang, X., Severo, M.S., Sakhon, O.S., Sohail, M., Brown, L.J., Sircar, M., Snyder, G.A., Sundberg, E.J., Ulland, T.K., Olivier, A.K., Andersen, J.F., Zhou, Y., Shi, G., Sutterwala, F.S., Kotsyfakis, M., Pedra, J.H.F. The Tick Salivary Protein Sialostatin L2 Inhibits Caspase-1-Mediated Inflammation during Anaplasma phagocytophilum Infection. Infect. Immun. Jun; 82(6): 2553-2564, 2014.

Ulland, T.K.*, Janowski, A.M.*, Buchan, B.W., Cassel, S.L., Jones, B.D., and Sutterwala, F.S. Francisella tularensis LVS Folate Metabolism and Pseudouridine Synthase Gene Mutants Modulate Macrophage Caspase-1 Activation. Infect. Immun. Jan; 81(1): 201-208, 2013.

Ulland, T.K. and Sutterwala F.S. Activation of the Inflammasome by Bacterial Pathogens. Invited book chapter for The Inflammasomes 2011.

Ulland, T.K., Buchan, B.W., Ketterer, M.R., Fernandes-Alnemri, T., Myerholz, D.K., Apicella, M.A., Alnemri, E.S., Jones, B.D., Nauseef, W.M., and Sutterwala, F.S. Cutting Edge: Mutation of Francisella tularensis mviN Leads to Increased Macrophage Absent in Melanoma 2 Inflammasome Activation and Loss of Virulence. J. Immunol. Sep 1; 185(5): 2670-2674, 2010.

Iyer, S.S., Pulskens, W.P., Sadler, J.J., Butter, L.M., Teske, G.J., Ulland, T.K., Eisenbarth, S.C., Florquin, S., Flavell, R.A., Leemans, J.C., and Sutterwala, F.S. Necrotic Cells Trigger a Sterile Inflammatory Response Through the NLRP3 Inflammasome. Proc. Natl. Acad. Sci. Dec; 106(48): 20388-93, 2009.

Moreland, J. G., Hook, J. S., Bailey, G., Ulland, T., and Nauseef, W.M. Francisella tularensis Directly Interacts with the Endothelium and Recruits Neutrophils with a Blunted Inflammatory Phenotype. Am. J. Physiol. Lung Cell. Mol. Physio. Jun; 296(6):L1076-84, 2009.