Luigi Puglielli

Position title: Professor, Department of Medicine


Phone: (608) 280-7000




M.D., Catholic University, Rome, Italy
Ph.D. in Molecular Medicine, Catholic University, Rome, Italy
Postdoctoral in Cell Biology, Catholic University, Santiago, Chile
Postdoctoral in Biochemistry, Boston University, Boston, MA, USA

Research Description:

My overall research interests are focused on molecular mechanisms of neurodevelopment and neurodegeneration across the lifespan. My laboratory employs a combination of biochemical, cellular, molecular, and genetic approaches in in vitro, ex vivo and in vivo models. In 2007 we reported that nascent proteins could undergo Nεlysine acetylation in the lumen of the endoplasmic reticulum (ER). This discovery resulted in the identification of a previously unknown biochemical machinery that impacts on the biology of the ER.

Research Focus:

Neurodevelopment, Neurodegenerative Diseases, Molecular Mechanisms and Pathogenesis

Link to Lab Website

Link to Publications