Seth S. Blair

Position title: Professor, Department of Integrative Biology


Phone: (608) 262-1345


Integrative Biology


Ph.D. in Zoology, University of California-Berkeley, Berkeley, CA, USA
Postdoctoral in Zoology, University of Washington, Seattle, WA, USA

Research Description:

Over the last two decades my laboratory has successfully used the powerful genetic and molecular advantages provided by Drosophila to analyze the patterning mechanisms underlying the development of the Drosophila wing. Using support from NIH and NSF, we have dissected the mechanisms underlying both the lineagebased cell fate decisions of compartmental lineage restrictions, and the signalingbased mechanisms that regulate cell determination and growth control in Drosophila and other animals. We have examined the roles of known signaling pathways (especially Wnt/Wingless, Notch, Hedgehog, and BMP), identified new extracellular modulators of these pathways (e.g. the Hedgehog and Wnt modulator Shifted/WIF1 and the BMP modulators Cv2/BMPER, CvTsg2 and Cvd), and identified and characterized a new mechanism of signaling mediated by the protocadherins Fat and Dachsous that regulates planar cell polarity and Hippobased growth control. My laboratory currently utilizes a wide range of techniques, from classical and molecular genetics to in vitro analyses of protein interaction to binding partner discovery.

Research Key Words:

Developmental Signaling, Patterning and Growth Control, Drosophila

Link to Lab Website

Link to Publications