Vaishali Bakshi

Position title: Associate Professor

Email: vbakshi@wisc.edu

Phone: (608) 265-6062

Department:

Psychiatry

Education:

Ph.D. in Neurosciences, University of California-San Diego

Research Description:

My lab investigates the neural substrates underlying core processes that are dysregulated in several mental illnesses, including Post Traumatic Stress Disorder and Schizophrenia. Using a molecule to behavior approach in rodents, we seek to characterize discrete neural circuits responsible for information-processing deficits that underly the symptoms of these illnesses. Our work combines behavioral analyses, pharmacology, chemogenetic manipulations, anatomical tracing, immunhistochemistry and cellular and molecular analyses of brain tissue in order to apply a truly systems-level approach to our research questions. A prominent area of investigation is how stress can modify these circuits to cause anxiety-like and cognitive deficits. We examine stress influence over various developmental stages, and identify manipulations that can mitigate the deleterious effects of stress, using translational paradigms for our preclinical work. Ultimately, we are interested in identifying novel treatment strategies for disorders like PTSD and Schizophrenia.

Key Words:

Neuropharmacology. cognition, stress, circuits, mental illness

Link to Publications