Jay Yang

Jay Yang
Professor, Department of Anesthesiology
(608) 265-6710


M.D. Washington University, St. Louis

Ph.D. Brown University

Lab Website:


Research Focus:

Molecular Mechanisms of Pathological pain, Gene Therapy for Pain, Modulation of Ligand and Voltage-gated Ion Channels

Research Strengths:

Behavior, Cognition, and Emotion; Neural Circuits; Neurobiology of Disease

Research Description:

Persistent agonizing pain long after the wound has healed is a clinical problem with no good treatment. We investigate the basic signaling pathways thought to mediate the transformation from acute injury to persistent pain. Various targets under investigation include the HCN an TTX-resistant ion channels responsible for the generation of spontaneous action potentials in the sensory nerve, and BDNF as a mediator leading to chloride-gradient reversal and excitation at inhibitory synapses in the spinal cord. Our long-range plan is to use the knowledge gained to come up with a gene-therapy approach using recombinant lentivirus or adeno-associated virus to treat pathological pain.


Please see PubMed for most recent publications.