Jose Martinez

M.P.A./Ph.D. Candidate

Advisor: Anita Bhattacharyya
Research Description:

My broad research interests are focused around molecular neuroscience. In the Spring of 2019, I joined the Bhattachargyya Lab located in the Waisman Center. My current research interest is studying Down Syndrome (DS). DS is a common genetic developmental disorder that leads to intellectual and developmental disability. While mouse models are crucial, they cannot explain all the complexities of human brain development making it important to examine the effects of trisomy 21 in the context of human cells. Human neural development in DS has not been well studied. Thus, we work with human pluripotent stem cells (trisomy 21 iPSCs) to study different aspects of cortical development in DS including interneuron development and the effects of oxidative stress on neuron function.