Paul A. Rutecki
- Professor and Vice Chairperson, Department of Neurology; Director of VA Northwest Epilepsy Center of Excellence
- (608) 263-5448
M.D. State University of New York at Buffalo
Understanding how abnormal neuronal synchronization occurs to produce seizures and how to intervene therapeutically to prevent seizures from occurring
The main goal of my laboratory is to understand the synaptic physiology of the hippocampus and how that circuitry favors epileptiform activity. We use the hippocampal slice preparation and intra- and extracellular recording techniques to study synaptic potentials and currents in CA3 pyramidal neurons. The hippocampal slice preparation is capable of generating epileptiform activity when convulsants are applied acutely or following lesions that alter the intrinsic synaptic circuitry.
The lab is now investigating the effects of activation of the metabotropic glutamate receptors (mGluR) on epileptiform activity and the development of a long lasting change in physiology that promotes abnormal synchronization. Group I agonists not only produce recurrent, synchronous neuronal oscillations, but following a 2-hour exposure induce a state of long-lasting changes in synaptic circuitry that favors synchronization. We believe that this phenomenon may contribute to the epileptogenesis, the development of epilepsy.
- Potter, WB, Basu, T, O’Riordan, KJ, Kirchner, A, Rutecki, P, Burger, C, Roopra (2013) Reduced juvenile long term depression in tuberous sclerosis complex mitigated in adults by compensatory recruitment of mGluR5 and ERK signaling. PLOS Biology, In press.
- Sillay, KA, Rutecki, P, Cicora K, Worrell, G, Drazkowski, J, Shih, JJ, Sharan, AD, Morrell, MJ, Williams, J, Wingeier, B (2013). Long-term measurement of impedance in chronically-implanted depth and subdural electrodes during responsive neurostimulation in humans. In press, Brain Simulation
- Dabbs K, Becker T, Jones J, Rutecki P, Seidenberg M, Hermann B. (2012) Brain structure and aging in chronic temporal lobe epilepsy, Epilepsia, 53::1033-43. PMID: 22471353
- Hutchinson EB, Rutecki PA, Alexander AL, Sutula TP (2012) Fisher statistics for analysis of diffusion tensor directional information. J Neurosci. Methods. 206:40-5. 2012 PMID: 22342971
- Karr, L, Pan, Y-Z, Rutecki, P. (2010) CB1 antagonism prevents induction of epileptiform activity by group I metabotropic glutamate receptor activation. Epilepsia, 51 (Suppl 3):121-125. PMCID 21269292 NIHMS ID: 20906
- Pan, Y-Z, Karr, L, Rutecki, P. (2010) Ictal activity induced by group I metabotropic glutamate receptor activation and loss of afterhyperpolarizations. Neuropharmacology, PMCID 20385148 NIHMS ID: 208235