Molecular neuroscientists seek to understand the development and function of the nervous system at the level of individual molecules and macromolecular complexes. This broad field encompasses researchers utilizing a variety of approaches to explore issues ranging from the structure and function of individual molecules such as ion channels to the molecular basis of behavior. For example, faculty in molecular neuroscience at the University of Wisconsin-Madison study the molecular basis of neuronal differentiation, axon guidance, synaptic transmitter release, ion channel gating, receptor-ligand interactions, cell signaling and cell death, to name a few areas. To perform these studies many researchers are taking a multidisciplinary approach applying protein biochemistry, molecular cloning, site directed mutagenesis, transgenesis, patch clamping, single and multiphoton microscopy, as well as other biophotonic based methods. In keeping with the interdisciplinary nature of the Neuroscience Training Program and the breadth of expertise of its faculty, many opportunities exist for cross-disciplinary collaborations with molecular neuroscientists.