Joseph W. Kemnitz
- Professor, Department of Cell and Regenerative Biology
- (608) 263-3588
Ph.D. University of Wisconsin-Madison
Energy Balance and Aging in Nonhuman Primates
My laboratory studies mechanisms controlling energy balance and on the consequences of caloric excess or deficit on physiological systems. Current experiments focus on the biology of aging and metabolic problems associated with mid- and late-life. One research focus concerns dietary restriction and aging. We are testing the hypothesis that a moderate reduction in caloric intake will slow the rate of aging and ultimately extend lifespan in primates as has been shown for rodents and some other short-lived species. Results thus far indicate that the monkeys on the reduced diet have less body fat, increased sensitivity to insulin and lower insulin levels, improved lipid profiles, and other changes that are consistent with better health. With leadership including other NTP faculty and students we are now extending these assessments to include brain imaging and cognitive function. Other projects have examined the pathogenesis of obesity and its complications, such as insulin resistance and diabetes mellitus. Pharmacologic interventions (e.g., neuropeptide analogs, adrenergic agonists) to promote maintenance of a healthy body weight and to ameliorate the complications of obesity also have been studied in this context.
- Fowler CG, Chiasson KB, Colman RJ, Kemnitz JW, Beasley TM, Weindruch RH. Hyperinsulinemia/diabetes, hearing, and aging in the University of Wisconsin calorie restriction monkeys. Hearing Research 2015 Jul 7;328:78-86.
- Sridharan, A., M. Pehar, M.S. Salamat, T.D. Pugh, B.B. Bendlin, A.A. Willette, R.M. Anderson, J.W. Kemnitz, R.J. Colman, R.H. Weindruch, L. Puglielli, and S.C. Johnson. 2013. Calorie restriction attenuates astrogliosis but not amyloid plaque load in aged rhesus macaques: a preliminary quantitative imaging study. Brain Research 2508:1-8.
- Willette, A.A., B.B. Bendlin, R.J. Colman, E.K. Kastman, A.S. Field, A.L. Alexander, A. Sridharan, D.B. Allison, R. Anderson, M.L. Voytko, J.W. Kemnitz, R.H. Weindruch, and S. Johnson. 2012. Calorie restriction reduces the influence of glucoregulatory dysfunction on regional brain volume in aged rhesus monkeys. Diabetes 61:1036-1042.
- Sridharan, A., A.A. Willette, B.B. Bendlin, A.L. Alexander, C.L. Coe, M.L. Voytko, R.J. Colman, J.W. Kemnitz, R.H. Weindruch, and S.C. Johnson. 2012. Brain volumetric and microstructural correlates of executive and motor performance in aged rhesus monkeys. Frontiers in Aging Neuroscience 4:1-19.
- Kemnitz, J.W. Calorie restriction and aging in nonhuman primates. 2011. ILAR Journal 52:66-77.
- Swanson, C.R, V. Joers, V. Bondarenko, K. Brunner, H.A. Simmons, T. E. Ziegler, J.W. Kemnitz, J.A. Johnson, and M.E. Emborg. 2011. The PPAR-g agonist pioglitazone modulates inflammation and induces neuroprotection in parkinsonian monkeys. Journal of Neuroinflammation 8:91-105.
- Colman R.J., R.M. Anderson, S.C. Johnson, E.K. Kastman, K.J. Kosmatka, T.M. Beasley, D.B. Allison, C. Cruzen, H.A. Simmons, J.W. Kemnitz and R. Weindruch. Caloric restriction delays disease onset and mortality in rhesus monkeys. 2009. Science 325:201-204,.