Craig W. Berridge

Craig Berridge
Title
Professor, Department of Psychology
Phone
(608) 265-5938
E-mail
berridge@wisc.edu

Education:

Ph.D. University of Florida

Lab Website:

http://psych.wisc.edu/berridge/berridge.html

Research Focus:

Neurobiology of Stress and Arousal

Research Strengths:

Behavior, Cognition, and Emotion; Neural Circuits

Research Description:

My research focuses on the behavioral and physiological functions of certain peptide and catecholamine neurotransmitters, particularly in the context of stress, arousal, and stimulant drugs. Currently there are 3 main themes: 1) Neurobiology of waking; 2) Neural mechanisms of amphetamine-induced arousal; 3) Neurobiology of stress and coping. Current work in the first category focuses on norepinephrine, dopamine and a newly-identified peptide, hypocretin, which has been linked recently to the sleep/arousal disorder, narcolepsy. Additionally, recent work begins to examine the neurobiology of clinically-relevant doses of methylphenidate (Ritalin) as used in the treatment of Attention Deficit Hyperactivity Disorder (ADHD).

We take a multidisciplinary approach in which a variety of methods are utilized, including pharmacological, electrophysiological, anatomical, and neurochemical techniques.

Publications:

Please see PubMed for most recent publications

  • Berridge CW, Schmeichel BE, España RA (2012) Noradrenergic regulation of sleep/wake state. Sleep Medicine Reviews, 16:187-197.
  • Spencer RC, Klein, R, Berridge CW (2012) Psychostimulants Act within the Prefrontal Cortex to Improve Cognitive Function.  Biological Psychiatry, 72:221-227.
  • España, R.A., K.M. Reis, R.J. Valentino, and C.W. Berridge. 2005. Organization of hypocretin efferents to locus coeruleus and basal forebrain arousal-related structures. Journal of Comparative Neurology 481:160-178.
  • Devilbiss DM, Jenison R, Berridge CW (2012) Stress-Induced Impairment of a Working Memory Task: Role of Spiking Rate and Spiking History Predicted Discharge. PLoS Computational Biology, 8(9): doi:10.1371/journal.pcbi.1002681
  • Schmeichel BE, Berridge, CW (2013) Neurocircuitry Underlying the Preferential Sensitivity of Prefrontal Catecholamines to Low-Dose Psychostimulants.  Neuropsychopharmacology. 38:1078-1084.
  • Spencer RC, Devilbiss DM, Berridge CW (2015) The cognition-enhancing effects of psychostimulants involve direct action in the Prefrontal Cortex.  Biological Psychiatry, 77:940-950.   
  • Berridge CW, Schmeichel BE, España RA (2016) Norepinephrine at the Nexus of Arousal, Motivation and Relapse.  Brain Research, 1641(Pt B):207-216 
  • Devilbiss DM, Spencer RC, Berridge CW (2016): Stress Degrades Prefrontal Cortex Neuronal Coding of Goal-Directed Behavior. Cerebral Cortex. doi: 10.1093/cercor/bhw140, epub ahead of print
  • Hupalo S, Berridge CW (2016): Working Memory Impairing Actions of Corticotropin-Releasing Factor (CRF) Neurotransmission in the Prefrontal Cortex. Neuropsychopharmacology, doi:10.1038/npp.2016.85. epub ahead of print