Darcie L. Moore

MooreDarcie
Title
Assistant Professor, Department of Neuroscience
Phone
608-265-7836
E-mail
darcie.moore@wisc.edu

Education:

Ph.D. University of Miami

Lab Website:

http://neuro.wisc.edu/faculty/moore.asp

Research Focus:

Neural stem cell aging

Research Strength:

Development, Plasticity, Repair, Molecular NeuroscienceNeurobiology of Disease

Research Description:

Neural stem cells (NSCs) are able to divide and asymmetrically generate new neurons in distinct regions of the adult mammalian brain in a process called adult neurogenesis. This ability decreases with age, contributing to cognitive decline. The molecular mechanisms behind this age-related decrease in neurogenesis are unclear.  Recently we have shown that NSCs asymmetrically segregate cargoes (e.g. damaged proteins) when they divide, leaving one daughter cell more “clean” than the other. The daughter cell which inherits the damage has a slower proliferation rate than the more “clean” daughter, suggesting that this process may be used for cellular rejuvenation (Moore et al, 2015 Science).  We have also found that this asymmetric segregation is dysregulated with age.  Thus, the research in my lab focuses on identifying the mechanisms that NSCs use to create the asymmetric segregation of cargoes, to identify what other components are segregated, and to use this knowledge to rescue the age-dependent decrease in adult hippocampal neurogenesis.

Selected Publications:

D.L. Moore, G.A. Pilz, M.J. Araúzo-Bravo, Y. Barral, S. Jessberger (2015).  A mechanism for the segregation of age in mammalian neural stem cells. Science, 349(6254): 1334-1338.

D.L. Moore, S. Jessberger. (2013). All astrocytes are not created equal - the role of astroglia in brain injury. EMBO Reports, 14(6): 487-8.

D.L. Moore, J.L. Goldberg (2011). Multiple transcription factor families regulate axon growth and regeneration. Developmental Neurobiology, 71(12): 1186-211.

D.L. Moore, A. Apara, and J.L. Goldberg (2011). Kruppel-Like Transcription Factors in the Nervous System: Novel players in neurite outgrowth and axon regeneration. Molecular and Cellular Neuroscience, 47(4): 233-43.

D.L. Moore and J.L. Goldberg (2010). Four steps to optic nerve regeneration. J Neuro-ophthalmology, 30(4): 347-60.

M.G. Blackmore, D.L. Moore, R.P. Smith, J.L. Goldberg, J.L. Bixby, and V.P. Lemmon (2010). High content screening of cortical neurons identifies novel regulators of axon growth. Molecular and Cellular Neuroscience, 44(1): 43-54. 

D.L. Moore, M.G. Blackmore, Y. Hu, K.H. Kaestner, J.L. Bixby, V.P. Lemmon, and J.L. Goldberg (2009). KLF Family Members Regulate Intrinsic Axon Regeneration Ability. Science, 326(5950): 298-301.