Linyuan Wang

E-mail: linyuan@wisc.edu

Research Project:

My recent research field stands in the Stem Cell’s potential roles in human neuron degeneration diseases. To explore cellular and molecular replacement strategies for treating motor neuron degeneration in ALS (Amyotrophic Lateral Sclerosis), I am currently doing mice transplantation surgeries in the SOD1 gene mutant animal models. The ultimate approach entails comprehensive analyses of both intrinsic properties and extrinsic factors that affect the survival of human motor neurons in the rodent model of familial ALS. After modifying human ESCs to independently express transgenes in motor neurons and astrocytes and identify intrinsic and extrinsic factors that support human motor neuron survival, the expected results of my studies may provide clues and guide new strategies in the treatment of this devastating disease.

Abstracts and Publications:

• Xi, Z., L. Wang, J. Sun, X. Liu, X. Zhu, and F. Xiao. 2007. TDAG51 in the anterior temporal neocortex of patients with intractable epilepsy. Neurosci Lett. 425:53-8. [PDF]
• Xi, Z., J. Sun, X. Wang, M. Li, X. Liu, L. Wang, X. Zhu, and F. Xiao. 2007. HSPBAP1 is Found Extensively in the Anterior Temporal Neocortex of Patients With Intractable Epilepsy. Synapse. 61:741-7.
• Xi, Z., X. Wang, R. He, M. Li, X. Liu, L. Wang, X. Zhu, F. Xiao, J. Sun, J. Li, and Y. Gong. 2007. Extracellular Signal-Regulated Protein Kinase in Human Intractable Epilepsy. Eur. J. Neurol. 14:865-72.
• Wang, L., and X. Liu. 2007. The function of copper in Alzheimer’s Disease. Journal of International Neurology and Neurosurgery. 34:9-93.
• Wang, L., M. Li, X. Huang, Y. Yu, and X. Liu. 2007. Copper’s influence on the Aβ degrading enzyme: Neprilysin in Alzheimer’s Disease. Journal of International Neurology and Neurosurgery.