Brady A. Riedner

Email: riedner@wisc.edu

Research Project:

My research is focused on the investigation of sleep in humans with high-density EEG. Sleep is an intriguing focus of neuroscientific study for at least two reasons: 1) the function of sleep is still unknown despite its pervasiveness in the animal kingdom and its power as a biological need; 2) sleep offers a unique view of the spontaneous activity of the brain unconfounded by attention and motivation. Our lab is capitalizing on the particular advantages of high-density (256 channels) EEG and advanced source localization techniques to study sleep. My primary interest is to better understand the spatiotemporal dynamics of the characteristic sleep events, such as slow waves and spindles, in order to better delineate their role in normal and abnormal sleep.

Abstracts and Publications:

• Ferrarelli, F., M. Massimini, M.J. Peterson, B.A. Riedner, M. Lazar, M.J. Murphy, R. Huber, M. Rosanova, A.L. Alexander, N. Kalin, and G. Tononi. 2008. Reduced evoked gamma oscillations in the frontal cortex in schizophrenia patients: a TMS/EEG study. Am. J. Psychiatry. [PDF]
• Riedner, B.A., V.V. Vyazovskiy, R. Huber, M. Massimini, S. Esser, M. Murphy, and G. Tononi. 2007. Sleep homeostasis and cortical synchronization: III. A high-density EEG study of sleep slow waves in humans. Sleep 30(12):1643-57. [PDF]
• Vyazovskiy, V.V., B.A. Riedner, C. Cirelli, and G. Tononi. 2007. Sleep homeostasis and cortical synchronization: II. A local field potential study of sleep slow waves in the rat. Sleep 30(12):1631-42. [PDF]
• Massimini, M., F. Ferrarelli, S.K. Esser, B.A. Riedner, R. Huber, M. Murphy, M.J. Peterson, and G. Tononi. 2007. Triggering sleep slow waves by transcranial magnetic stimulation. PNAS. In press.
• Ferrarelli, F., R. Huber, M.J. Peterson, M. Massimini, M. Murphy, B.A. Riedner, A. Watson, P. Bria, and G. Tononi. 2007. Reduced sleep spindle activity in schizophrenia patients. Amer. J of Psychiatry. 64: 483-492. [PDF]
• Tononi, G., M. Massimini, and B.A. Riender. 2006. Sleep dialogues between cortex and hippocampus: who talks to whom? Neuron 52: 748-749. [PDF]
• Huber, R., M.F. Ghilardi, M. Massimini, F. Ferrarelli, B.A. Riedner, M.J. Peterson, and G. Tononi. 2006. Arm immobilization causes cortical plastic changes and locally decreases sleep slow wave activity. Nature Neurosci. 9: 1169-1176. [PDF]
• Parsons, R.G., G.M. Gafford, D.E. Baruch, B.A. Riedner, and F.J. Helmstetter. 2006. Long-term stability of fear memory depends on the synthesis of protein but not mRNA in the amygdala. J. of Neurosci. 23: 1853-1859. [PDF]
• Parsons, R.G., B.A. Riedner, G.M. Gafford, and F.J. Helmstetter. 2006. The formation of auditory fear memory requires the synthesis of protein and mRNA in the auditory thalamus. Neurosci. 141: 1163-1170. [PDF]
• Riedner, B.A., V.V. Vyazovskiy, R. Huber, M. Massimini, S. Hill, and G. Tononi. 2006. Sleep homeostasis, slow waves and cortical synchronization: III. A high-density EEG study in humans. Assoc. Prof. Sleep Soc. Abstr. [PDF]
• Lazar, M., M. Massimini, F. Ferrarelli, B.A. Riedner, J.H. Lee, A.L. Alexander, and G. Tononi. 2005. Investigation of anatomical and effective connectivity using White Matter Tractography and Transcranial Magnetic Stimulation. Magnetic Resonance in Med Abstr.