Michael Murphy

 

 

Email: mjmurphy2@wisc.edu

Research Project:

I am using source imaging methods to improve the spatial resolution of EEG and better understand what is occurring in the brain during sleep and waking.  In particular, I am working on determining the cortical structures responsible for the initiation, maintenance, and propagation of EEG sleep slow waves.

I am measuring connectivity and complexity in the cortical space.  One measure of complexity I am using is called Multiscale Entropy.  With this, I examine the complexity of the sleeping and waking brain as well as differences in entropy between control and psychiatric subjects. This work may eventually help with the diagnosis of various disorders as well as shedding light on the neural substrates that give rise to the complex phenotypes of psychiatric disorders.

Abstracts and Publications:

• Riedner, B.A., V.V. Vyazovisky, R. Huber, M. Massimini, S. Esser, M. Murphy, G. Tononi. 2007. Sleep homeostasis and cortical synchronization: III. A high-density EEG study of sleep slow waves in humans. Sleep 30(12):1643-57. [PDF]
• Massimini, M., F. Ferrarelli, S.K. Esser, B.A. Riedner, R. Huber, M. Murphy, M.J. Peterson, and G. Tononi. 2007. Triggering sleep slow waves by transcranial magnetic stimulation. PNAS. In press.
• Ferrarelli, F., R. Huber, M.J. Peterson, M. Massimini, M. Murphy, B.A. Riedner, A. Watson, P. Bria, and G. Tononi. 2007. Reduced sleep spindle activity in schizophrenia patients. Amer. J. Psychiatry. 164: 483-942. [PDF]
• Struck, A.F., M.J. Murphy, and B.J. Iskandar. 2006. Spontaneous development of a de novo suprasellar arachnoid cyst. J. Neurosurg. 104: 426-428. [PDF]