Courtney Guenther

E-mail: cguenther@wisc.edu

Research Project:

The Mitchell lab explores a form of respiratory neuroplasticity referred to as long term facilitation. This plasticity can be elicited under conditions of repeated intermittent hypoxia and involves serotonin-dependent synthesis of key trophic factors such as BDNF. LTF has applications in a wide variety of areas including spinal cord injury, sleep apnea, and ALS.

Abstracts and Publications:

• Guenther, C.A., E.A. Dale-Nagle, and G.S. Mitchell. 2008. BDNF protein exhibits a circadian rhythm in the hypoglossal, but not phrenic, motor nucleus. Exper. Biol. Conf. Abstr.
• Morris, M.T., C. DeBruin, Z. Yang, J.W. Chambers, K.S. Smith, and J.C. Morris. 2006. Activity of a second Trypanosoma brucei hexokinase is controlled by an 18 amino acid C-terminal tail. Eukaryotic Cell. 5: 2014-2023. [PDF]
• Chambers, J., C. DeBruin, M. Morris, and J.C. Morris. 2006. Characterization of two nearly identical hexokinases from Trypanosoma brucei. 16th Annual Molecular Parasitology/Vector Biology Symp. Abstr.
• Morris, J.C., C. DeBruin, and M.T. Morris. 2006. Exploring the role of hexokinases in the glucose sensing pathway in Trypansoma brucei. Gordon Res. Conf. “The Biology of Host-Parasite Interactions” Abstr.
• Morris, J.C., C. DeBruin, C. Seifert, C. Ridings, and M.T. Morris. 2005. Connecting glycolysis to surface molecule expression-building the glucose sensing pathway in Trypanosoma brucei. Kinetoplastic Mol. Cell Biol. Int. Conf. Abstr.