Min Dong

Research Project:

I am working on how botulinum neurotoxins (BoNTs) recognize target neurons and how to block these deadly toxins. In the previous studies, we demonstrated synaptotagmin (syt) I and II, two synaptic vesicle membrane proteins, mediate one of botulinum neurotoxins, BoNT/B, into cells. We are currently working on the details of syt-BoNT/B interactions, and started to look for cellular receptors of other botulinum neurotoxins. We also developed a new method to detect these toxins both in vitro, and inside live cells. This CFP/YFP based method paved the way for large-scale screening of toxin inhibitors in the future.

Abstracts and Publications:

Dong, M., D.A. Richards, M.C. Goodnough, W.H. Tepp, E.A. Johnson, and E.R. Chapman. 2003. Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells. J. Cell. Biol. 162(7): 1293-303. [PDF]
Lewis, J.L., M. Dong, C.A. Earles, and E.R. Chapman. 2001. The transmembrane domain of syntaxin 1A is critical for the interaction of its cytoplasmic domain protein-protein interactions. J. Biol. Chem. 276: 15458-15465. [PDF]


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Min Dong E-mail: mdong@wisc.edu Research Project: I am working on how botulinum neurotoxins (BoNTs) recognize target neurons and how to block these deadly toxins. In the previous studies, we demonstrated synaptotagmin (syt) I and II, two synaptic vesicle membrane proteins, mediate one of botulinum neurotoxins, BoNT/B, into cells. We are currently working on the details of syt-BoNT/B interactions, and started to look for cellular receptors of other botulinum neurotoxins. We also developed a new method to detect these toxins both in vitro, and inside live cells. This CFP/YFP based method paved the way for large-scale screening of toxin inhibitors in the future. Abstracts and Publications: Dong, M., D.A. Richards, M.C. Goodnough, W.H. Tepp, E.A. Johnson, and E.R. Chapman. 2003. Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells. J. Cell. Biol. 162(7): 1293-303. [PDF] Lewis, J.L., M. Dong, C.A. Earles, and E.R. Chapman. 2001. The transmembrane domain of syntaxin 1A is critical for the interaction of its cytoplasmic domain protein-protein interactions. J. Biol. Chem. 276: 15458-15465. [PDF]

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