Ronald E. KalilRonald E. Kalil

 

 

Neural Stem Cells, Adult Neurogenesis and the Injured Brain

E-mail: rekalil@wisc.edu

Office Phone: (608) 262-4903, (608) 265-2072

Research Strength: Development: Plasticity and Repair

When the brain is damaged, injured neurons die and typically are not replaced.  This cell death most often results in a loss of function by the affected region of the brain. However, if neurons that have died could be replaced and their connections rebuilt, normal function might be restored.  A possible approach to achieve this goal involves transplanting neural stem cells to the injured brain, and then coaxing them to differentiate into new, functionally appropriate neurons and glial cells.  Currently, we are transplanting human neural stem cells to the normal and injured adult rat brain to determine whether the transplanted cells differentiate appropriately and integrate with the host brain.

In the hippocampus of every mammalian species that has been studied, including humans, new neurons are produced daily.  We are studying hippocampal neurogenesis in normal adult rats to determine the rate of new neuron production and the survival of newly generated neurons.  This research is a first step in exploring whether administering a trio of chemotherapeutic drugs commonly used in treating breast cancer interferes with the generation or survival of new neurons in the hippocampus.  If so, the work may shed light on a debilitating side effect of chemotherapy, cognitive dysfunction, commonly known as "chemobrain."Many cells cultured from the cholinergic basal forebrain of the adult rat express nestin (yellow

In parallel with these two lines of research, we have discovered neural cells in several areas of the adult rat and human brain that the common wisdom would argue should not exist at any stage of neural development or maturation.  These unique cells express the cytoskeletal protein nestin, heretofore associated only with neural stem cells, as well as proteins expressed exclusively by mature neurons.  The co-expression of nestin and markers of mature neurons suggests that these cells, which we have named nestin neurons, may have stem cell-like properties, and we now are characterizing nestin neurons to determine if they are capable of functioning as endogenous neural stem cells in plasticity-related behavior.

 

Lab Website:

http://www.keck.bioimaging.wisc.edu/

Selected Publications:

   
         
   

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