Sterling C. Johnson

 

 

Studies of Brain Function in Patients with Cognitive Disorders

E-mail: scj@medicine.wisc.edu

Research Strengths: Neurobiology of Disease

In my lab we use brain imaging in conjunction with neuropsychological measurement to study cognitive disorders of memory and self-awareness. The lab seeks to address questions such as: How early in life does Alzheimer Disease begin and can functional imaging provide new knowledge about presymptomatic disease progression? What are the neural substrates of awareness (or unawareness) of deficit in AD and other cognitive disoders? To answer questions like these we collaborate with a talented multi-disciplinary team, and study healthy volunteers across the age spectrum with and without risk factors for dementia, patients with Alzheimer's disease, Mild Cognitive Impairment, frontal temporal dementias, and patients with traumatic brain injury.

Lab Website:

http://www.brainmap.wisc.edu/scj.html

Selected Publications:

• Trivedi, M.A., T.W. Schmitz, M.L. Ries, B.M. Torgerson, M.A. Sager, B.P. Hermann, S. Asthana, and S.C. Johnson. 2006. Reduced hippocampal activation during episodic encoding in middle-aged individuals at genetic risk for Alzheimer’s Disease: A cross-sectional study. BMC Medicine 4:1. [Open Access]
• Ries, M.L., T.A. Schmitz, T.N. Kawahara, B.M. Torgerson, M.A. Trivedi, and S.C. Johnson. 2006. Task-dependent posterior cingulate activation in mild cognitive impairment. Neuroimage 29: 485-492.
• Johnson, S.C., T.W. Schmitz, H.A. Rowley, A.L. Alexander, J. Lee, and R.J. Davidson. 2005. The cerebral response during subjective choice with and without self-reference. J. Cogn. Neurosci. 17: 1897-1906.
• Gleason, C.E., C.M. Carlsson, S.C. Johnson, C. Atwood, and S. Asthana. 2005. Clinical pharmacology and differential cognitive efficacy of estrogen preparations. Ann. N.Y. Acad. Sci. 1052: 93-115.
• Hua, L.H., I.A. Strigo, L.C. Baxter, S.C. Johnson, and A.D. Craig. 2005. Antero-posterior somatotopy of innocuous cooling activation focus in human dorsal posterior insular cortex. Am. J. Physiol. 289: R319 - R325.