Zsuzsanna Fabry

 

 

Immune Reactivity in the CNS

E-mail: zfabry@wisc.edu

Research Strength: Neurobiology of Disease

There are a number of important human central nervous system (CNS) diseases of poorly understood autoimmune etiology which are characterized by the presence of inflammatory cell infiltrates in the CNS and immune-mediated disruption of CNS function. One example is Multiple Sclerosis (MS) which is a chronic inflammatory demyelinating disease of the CNS. The pathogenesis of this disease is very difficult to understand for the following reasons: 1.) The autoantigen against which the initial immunopathological response is directed is largely unknown. 2.) The cell types presenting the autoantigens are not well identified. 3.) No single immune mediator or cell had been pinpointed as a key factor in damaging the local tissue elements. 4.) The mechanism of T cell migration across the blood-brain-barrier and the immunological survey of the CNS are not well understood. The goal of my studies is to address these issues and to understand the pathogenesis of inflammations in the CNS. We believe that the successful completion of our research will lead the foundation for new therapeutic ways aimed at controlling of CNS inflammation and MS.

Selected Publications:

• Baiu, D.C., B. Barger, M. Sandor, Z. Fabry, and M.N. Hart. 2005. Autoantibodies to vascular smooth muscle are pathogenic for vasculitis. Am. J. Pathol. 166: 1851-1860. [PDF]
• Darabi, K., A.Y. Karulin, B.O. Boehm, H. H. Hofstetter, Z. Fabry, J.C. LaManna, J.C. Chavez, M. Tary-Lehmann, and P.V. Lehmann. 2004. The third signal in T cell-mediated autoimmune disease? J. Immunol. 173: 92-99. [PDF]
• Fee, D.B., D.L. Sewell, K. Andresen, T.J. Jacques, S. Piaskowski, B.A. Barger, M.N. Hart, and Z. Fabry. 2004. Traumatic brain injury increases TGFbetaRII expression on endothelial cells. Brain Res. 1012: 52-59. [PDF]
• Karman, J., C. Ling, M. Sandor, and Z. Fabry. 2004. Dendritic cells in the initiation of immune responses against central nervous system-derived antigens. Immunol. Lett. 92: 107-115.
• Karman, J., C. Ling, M. Sandor, and Z. Fabry. 2004. Initiation of immune responses in brain is promoted by local dendritic cells. J. Immunol. 173: 2353-2361. [PDF]
• Sewell, D. L., B. Nacewicz, F. Liu, S. Macvilay, A. Erdei, J.D. Lambris, M. Sandor, and Z. Fabry. 2004. Complement C3 and C5 play critical roles in traumatic brain cryoinjury: Blocking effects on neutrophil extravasation by C5a receptor antagonist. J. Neuroimmunol. 155: 55-63. [PDF]
• Sewell, D. L., E.K. Reinke, D.O. Co, L.H. Hogan, R.B. Fritz, M. Sandor, and Z. Fabry. 2003. Infection with mycobacterium bovis BCG diverts traffic of myelin oligodendroglial glycoprotein autoantigen-specific T cells away from the central nervous system and ameliorates experimental autoimmune encephalomyelitis. Clin. Diagn. Lab Immunol. 10: 564-572. [PDF]
• Swanson, B. J., D.C. Baiu, M. Sandor, Z. Fabry, and M.N. Hart. 2003. A small population of vasculitogenic T cells expands and has skewed T cell receptor usage after culture with syngeneic smooth muscle cells. J. Autoimmun. 20: 125-133.
• Fee, D., A. Crumbaugh, T. Jacques, B. Herdrich, D. Sewell, D. Auerbach, S. Piaskowski, M.N. Hart, M. Sandor, and Z. Fabry. 2003. Activated/effector CD4(+) T cells exacerbate acute damage in the central nervous system following traumatic injury. J. Neuroimmunol. 136: 54-66. [PDF]
• Hofstetter, H.H., D.L. Sewell, F. Liu, M. Sandor, T. Forsthuber, P.V. Lehmann, and Z. Fabry. 2003. Autoreactive T cells promote post-traumatic healing in the central nervous system. J. Neuroimmunol. 134: 25-34. [PDF]
• Sewell, D., Qing, Z., E. Reinke, D. Elliot, J. Weinstock, M. Sandor, and Z. Fabry. 2003. Immunomodulation of experimental autoimmune encephalomyelitis by helminth ova immunization. Int. Immunol. 15: 59-69. [PDF]
• Sewell, D.L., E. Reinke, L.H. Hogan, M. Sandor, and Z. Fabry. 2002. Immunoregulation of CNS autoimmunity by helminth and mycobacterial infections. Immunol. Lett. 82: 101-110. [PDF]
• Swartz, K.R, F. Liu, D. Sewell, T. Schochet, I. Campbell, M. Sandor, and Z. Fabry. 2001. Interleukin-6 promotes post-traumatic healing in the central nervous system. Brain Res. 896: 86-95. [PDF]
• Fee, D., D. Grzybicki, M. Dobbs, S. Ihlyer, J. Clotfelter, S. Macvilay, M.N. Hart, M. Sandor, and Z. Fabry. 2000. Interleuken 6 promotes vasculogenesis of murine brain microvessel endothelial cells. Cytokine 12: 655-665.
• Qing, Z., D. Sewell, M. Sandor, and Z. Fabry. 2000. Antigen-specific T cell trafficking into the central nervous system. J. Neuroimmunol. 105: 169-178.