Craig W. Berridge

 

 

Neurobiology of Stress and Arousal

E-mail: berridge@wisc.edu

Research Strengths: Behavior: Cognition and Emotion, Neural Circuits

My research focuses on the behavioral and physiological functions of certain peptide and catecholamine neurotransmitters, particularly in the context of stress, arousal, and stimulant drugs. Currently there are 3 main themes: 1) Neurobiology of waking; 2) Neural mechanisms of amphetamine-induced arousal; 3) Neurobiology of stress and coping. Current work in the first category focuses on norepinephrine, dopamine and a newly-identified peptide, hypocretin, which has been linked recently to the sleep/arousal disorder, narcolepsy. Additionally, recent work begins to examine the neurobiology of clinically-relevant doses of methylphenidate (Ritalin) as used in the treatment of Attention Deficit Hyperactivity Disorder (ADHD).

We take a multidisciplinary approach in which a variety of methods are utilized, including pharmacological, electrophysiological, anatomical, and neurochemical techniques.

Lab Website:

http://psych.wisc.edu/berridge/

Selected Publications:

• Devilbiss, D.M. and C.W. Berridge. 2006. Actions of low-dose methylphenidate (Ritalin) on tonic and phasic locus coeruleus discharge. Journal of Pharmacological and Experimental Therapeutics 319:1327-1335 [PDF]
• Berridge, C.W. 2006. Neural Substrates of Psychostimulant-Induced Arousal. Neuropsychopharmacology 31:2332-2340. [PDF]
• Berridge, C.W., D.M. Devilbiss, M.E. Andrzejewski, A.F.T. Arnsten, A.E. Kelley, B. Schmeichel, C. Hamilton, R.C. Spencer. 2006. Methylphenidate preferentially increases catecholamine neurotransmission within the prefrontal cortex at low doses that enhance cognitive function. Biological Psychiatry 60:1111-1120. [PDF]
• España, R.A. and C.W. Berridge. 2006. Organization of locus coeruleus efferents to basal forebrain arousal-related structures. Journal of Comparative Neurology 496:668-683.
• Vittoz, N.M. and C.W. Berridge. 2006. Hypocretin selectively increases dopamine efflux within the prefrontal cortex. Neuropsychopharmacology 31:384-395. [PDF]
• Berridge, C.W. and R.A. España. 2005. Hypocretins: Waking, Arousal or Action? Neuron 46:696-698. [PDF]
• España, R.A., K.M. Reis, R.J. Valentino, and C.W. Berridge. 2005. Organization of hypocretin efferents to locus coeruleus and basal forebrain arousal-related structures. Journal of Comparative Neurology 481:160-178. [PDF]
• Stalnaker, T.A. and C.W. Berridge. 2003. AMPA Receptor stimulation within the central nucleus of the amygdala elicits a differential activation of central dopaminergic systems. Neuropsychopharmacology 28:1923-1934. [PDF]
• España, R.A., R.J. Valentino, and C.W. Berridge. 2003. Fos immunoreactivity in hypocretin-synthesizing and hypocretin 1-receptor-expressing neurons: effects of diurnal and nocturnal spontaneous waking, stress and hypocretin-1 administration. Neuroscience 121:201-217. [PDF]
• Berridge, C.W., S. Isaac, and R.A. Espana. 2003. Additive wake-promoting actions of medial basal forebrain noradrenergic a1- and b-receptor stimulation. Beh. Neurosci. 117: 350-359. [PDF]
• Berridge, C.W. and B.D. Waterhouse. 2003. Modulatory actions of the locus coeruleus-noradrenergic system on behavioral state and state-dependent cognitive processes. Brain Res. Rev. 42: 33-84. [PDF]
• Berridge, C.W. and T.A. Stalnaker. 2002. Relationship between low-dose amphetamine-induced arousal and extracellular norepinephrine and dopamine levels within prefrontal cortex. Synapse 46: 140-149. [PDF]
• Espana, R.A., B. Baldo, A.E. Kelley, and C.W. Berridge. 2001. Wake-promoting and sleep-suppressing actions of hypocretin (orexin): Basal forebrain sites of action. Neuroscience 106: 699-715. [PDF]
• Berridge, C.W. and R. Espana. 2000. Synergistic sedative effects of noradrenergic a1- and b-receptor blockade on forebrain electroencephalographic and behavioral indices. Neuroscience 99: 495-505. [PDF]
• Berridge, C.W., E. Mitton, W. Clark, and R.H. Roth. 1999. Engagement in a non-escape (displacement) behavior elicits a selective and lateralized suppression of frontal cortical dopaminergic utilization in stress. Synapse 32: 187-197. [PDF]
• Berridge, C.W. and E.D. Abercrombie. 1999. Relationship between locus coeruleus discharge rates and rates of norepinephrine release within neocortex as assessed by in vivo microdialysis. Neuroscience 93: 1263-1270. [PDF]
• Berridge, C.W., J. O'Neil, and K. Wifler. 1999. Amphetamine acts within the basal forebrain to initiate and maintain alert waking. Neuroscience 93: 885-896. [PDF]