Neurobiology of Stress and Arousal
Office Phone: (608) 265-5938, (608) 262-1040
My research focuses on the behavioral and physiological functions of certain peptide and catecholamine neurotransmitters, particularly in the context of stress, arousal, and stimulant drugs. Currently there are 3 main themes: 1) Neurobiology of waking; 2) Neural mechanisms of amphetamine-induced arousal; 3) Neurobiology of stress and coping. Current work in the first category focuses on norepinephrine, dopamine and a newly-identified peptide, hypocretin, which has been linked recently to the sleep/arousal disorder, narcolepsy. Additionally, recent work begins to examine the neurobiology of clinically-relevant doses of methylphenidate (Ritalin) as used in the treatment of Attention Deficit Hyperactivity Disorder (ADHD).
We take a multidisciplinary approach in which a variety of methods are utilized, including pharmacological, electrophysiological, anatomical, and neurochemical techniques.
- Devilbiss, D.M. and C.W. Berridge. 2006. Actions of low-dose methylphenidate (Ritalin) on tonic and phasic locus coeruleus discharge. Journal of Pharmacological and Experimental Therapeutics 319:1327-1335
- Berridge, C.W. 2006. Neural Substrates of Psychostimulant-Induced Arousal. Neuropsychopharmacology 31:2332-2340.
- Berridge, C.W., D.M. Devilbiss, M.E. Andrzejewski, A.F.T. Arnsten, A.E. Kelley, B. Schmeichel, C. Hamilton, R.C. Spencer. 2006. Methylphenidate preferentially increases catecholamine neurotransmission within the prefrontal cortex at low doses that enhance cognitive function. Biological Psychiatry 60:1111-1120.
- España, R.A. and C.W. Berridge. 2006. Organization of locus coeruleus efferents to basal forebrain arousal-related structures. Journal of Comparative Neurology 496:668-683.
- Vittoz, N.M. and C.W. Berridge. 2006. Hypocretin selectively increases dopamine efflux within the prefrontal cortex. Neuropsychopharmacology 31:384-395.
- Berridge, C.W. and R.A. España. 2005. Hypocretins: Waking, Arousal or Action? Neuron 46:696-698.
- España, R.A., K.M. Reis, R.J. Valentino, and C.W. Berridge. 2005. Organization of hypocretin efferents to locus coeruleus and basal forebrain arousal-related structures. Journal of Comparative Neurology 481:160-178.
- Stalnaker, T.A. and C.W. Berridge. 2003. AMPA Receptor stimulation within the central nucleus of the amygdala elicits a differential activation of central dopaminergic systems. Neuropsychopharmacology 28:1923-1934.
- España, R.A., R.J. Valentino, and C.W. Berridge. 2003. Fos immunoreactivity in hypocretin-synthesizing and hypocretin 1-receptor-expressing neurons: effects of diurnal and nocturnal spontaneous waking, stress and hypocretin-1 administration. Neuroscience 121:201-217.
- Berridge, C.W., S. Isaac, and R.A. Espana. 2003. Additive wake-promoting actions of medial basal forebrain noradrenergic a1- and b-receptor stimulation. Beh. Neurosci. 117: 350-359.
- Berridge, C.W. and B.D. Waterhouse. 2003. Modulatory actions of the locus coeruleus-noradrenergic system on behavioral state and state-dependent cognitive processes. Brain Res. Rev. 42: 33-84.
- Berridge, C.W. and T.A. Stalnaker. 2002. Relationship between low-dose amphetamine-induced arousal and extracellular norepinephrine and dopamine levels within prefrontal cortex. Synapse 46: 140-149.
- Espana, R.A., B. Baldo, A.E. Kelley, and C.W. Berridge. 2001. Wake-promoting and sleep-suppressing actions of hypocretin (orexin): Basal forebrain sites of action. Neuroscience 106: 699-715.
- Berridge, C.W. and R. Espana. 2000. Synergistic sedative effects of noradrenergic a1- and b-receptor blockade on forebrain electroencephalographic and behavioral indices. Neuroscience 99: 495-505.
- Berridge, C.W., E. Mitton, W. Clark, and R.H. Roth. 1999. Engagement in a non-escape (displacement) behavior elicits a selective and lateralized suppression of frontal cortical dopaminergic utilization in stress. Synapse 32: 187-197.
- Berridge, C.W. and E.D. Abercrombie. 1999. Relationship between locus coeruleus discharge rates and rates of norepinephrine release within neocortex as assessed by in vivo microdialysis. Neuroscience 93: 1263-1270.
- Berridge, C.W., J. O'Neil, and K. Wifler. 1999. Amphetamine acts within the basal forebrain to initiate and maintain alert waking. Neuroscience 93: 885-896.