Anthony P. Auger
Neuroendocrinology of Sex Differences in Brain and Behavior
E-mail: apauger@wisc.edu
Research Strengths: Behavior: Cognition and Emotion, Development: Plasticity and Repair, Molecular Neuroscience
As there are sex differences in some neurological and psychiatric disorders (e.g., autism, depression, and Alzheimer's disease), it is important to understand how steroid receptors act in the brain during development to induce lasting changes in sexually dimorphic behaviors and physiology. My research focuses on how steroid receptors act during development to differentiate male from female brain. Steroid receptor action in the developing brain can have lasting effects on neuronal morphology, neurotransmitter content, and brain structure, which are different in male versus female brain. Themes include: 1) Understanding how steroid receptor action during development produces sex differences in brain physiology and behavior. 2) How steroid receptor action is influenced by non-steroidal mechanisms, such neurotransmitters or through social interactions. 3) Identifying sex differences in gene expression during development and determine the functional consequences of these genes on adult physiology and behavior. We use a variety of techniques to understand how sex differences are produced in the brain, such as immunocytochemistry, in situ hybridization, Western Immunoblots, tissue culture, PCR, and behavioral analysis. We also use cutting-edge techniques, such as identification of gene expression using DNA arrays and manipulation of gene expression using antisense technology. In many studies, we use a multi-level approach ranging from examination of gene expression to behavioral analysis.
Lab Website:
Selected Publications:
- Auger, A.P. 2003. Sex differences in the developing brain: Crossroads in the phosphorylation of cAMP response element binding protein. J. Neuroendocrinol. 15: 622-627.
- Auger, A.P., T.S. Perrot-Sinal, and M.M. McCarthy. 2001. Excitatory versus inhibitory GABA as a divergence point in steroid-mediated sexual differentiation of the brain. Proc. Nat. Acad. Sci. 98: 8059-8064. [PDF]
- Auger, A.P., M.J. Tetel, and M.M. McCarthy. 2000. Steroid receptor coactivator-1 (SRC-1) mediates the development of sex-specific brain morphology and behavior. Proc. Nat. Acad. Sci. 97: 7551-7555. [PDF]